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Deep Sequencing and Haplotype Profiling of Mental Disorders

Published on AidPage by IDILOGIC on Jun 24, 2005
Administered by:

Department of Health and Human Services, National Institutes of Health, National Institutes of Health
(see all US Federal Agencies)

Explore all postings for this grant program:
  • Original Grant - May 10, 2005
Applications Due:

Multiple Receipt Dates - See Link to Full Announcement for details.

total funding: $7,500,000
max award: $2,500,000
min award: none
cost sharing, matching: No
number of awards: Not Available
type of funding: Grant

With the initial stages of the Human Genome Project completed and new insights gained into the complex interplay of genomic function, genomic structure and the environment in mental disorders, attention is shifting towards the translational promise of the completed human sequence and a new era of genomic medicine in mental disorders. However, there are still major obstacles that need to be addressed before this occurs. It will be necessary to see a confluence of developments in genomic technologies and epidemiological methods, such as high throughput sequencing of candidate genes or genomic regions; global single nucleotide polymorphism (SNP) or haplotype analysis; improved measurements of environmental factors; well-characterized clinical phenotypes and endophenotypes; and the development of new analytical approaches. Furthermore, these advances will have to be applied in carefully crafted study designs and, implicitly, in large samples. A special emp!
hasis of this initiative is to support applications that implement large-scale studies and innovative analytical designs that will disaggregate a given mental disorder into components of finite risks. These developments may be evolutionary or may be fundamentally new and may lead to paradigm shifts in the field. Applications written in response to this PA may propose new technologies for cost effective whole genome analysis and in-depth sequencing and analysis of candidate genes and genomic regions in pedigrees or in a sample of unrelated cases with mental disorders. Proposals for large-scale haplotype analysis and the development of new analytical methods also are encouraged. Projects funded under this program will focus on phenotypically well-characterized samples from the NIMH Human Genetics Initiative (http://nimhgenetics.org/) but may also use existing sample collections not included in the repository and study one of seven mental disorders: anorexia nervosa, attention!
deficit hyperactivity disorder, autism and related autism spectrum di
sorders, depression, bipolar disorder, obsessive compulsive disorder and schizophrenia. To take into account the rapid technological and scientific developments now occurring in genetics, proposals funded under this initiative will be restricted to a three-year period. Results from research funded under this initiative will have direct implications for diagnosis, treatment and ultimately prevention of mental disorders.

Who can apply:

Anyone/General Public
City Or Township Governments
County Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Minority Group
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Profit Organization
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Quasi-Public Nonprofit Institution/Organization
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)

Eligible functional categories:
Funding Sources:

Mental Health Research Grants

More Information:


If you have problems accessing the full announcement, please contact: NIH OER Webmaster

Address Info:

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